XYLID-P TAB
November 30, 2017
OXECRA SUSP.
November 30, 2017

ZIMFE-200 TAB.

(ACECLOFENAC 200 MG)

Description

Packing: – 10X10
M.R.P: – 450
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.
PHARMACOLOGY
PHARMACODYNAMICS:
Aceclofenac is a non-steroidal agent with marked anti-inflammatory and analgesic properties. The mode of action of aceclofenac is largely based on the inhibition to prostaglandin synthesis. Aceclofenac is a potent inhibitor of the enzyme cyclo-oxygenase, which is involved in the production of prostaglandins.
PHARMACOKINETICS:
• Absorption: – After oral administration, aceclofenac is rapidly and completely absorbed as unchanged drug.
• Distribution: – Peak plasma concentrations are reached approximately 1.25 to 3.00 hours following ingestion. Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 57% of those in plasma. The volume of distribution is approximately 25 L.
• Elimination: – The mean plasma elimination half-life is around 4 hours. Aceclofenac is highly protein- bound (>99%). Aceclofenac circulates mainly as unchanged drug. 4- hydroxyl-aceclofenac is the main metabolite detected in plasma. Approximately two- thirds of the administered dose is excreted via the urine, mainly as hydroxyl-metabolites. No changes in the pharmacokinetics of aceclofenac have been detected in the elderly.
INDICATIONS:
This medication is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever, pain, ankylosing spondylitis and arthritis. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation. It blocks the action of a substance in the body (cyclo-oxygenase), which may cause pain, swelling and inflammation.

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