(CEFIXIME 200 MG + AZITHROMYCIN 250 MG)
Packing: – 10X1X10
M.R.P: – 2200
Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsilitis, and pharyngitis. The usual dose is 400 mg in two divided doses for up to 5-7 days. Pharmacokinetics
Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Absorption Only 40-50% is absorbed from the GI tract (oral); rate may be decreased if taken with food. Greater absorption from oral suspension than tablets. Distribution Bile, urine (high concentrations); crosses the placenta.
Excretion 20% of an oral dose excreted via urine unchanged; 60% nonrenal elimination; some is excreted via the faeces from the bile. Substantially removed by dialysis. Azithromycin is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world’s best-selling antibiotics, and is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring, thus making the lactone ring 15-membered. Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, tonsillitis, throat infections, laryngitis, bronchitis, pneumonia, Typhoid, and sinusitis. In recent years it has primarily been used to prevent bacterial infections in infants and those with weaker immune systems. It is also effective against certain urinary tract infections, such as non-gonococcal urethritis and cervicitis. Recent studies have also indicated it to be effective against late-onset asthma, but these findings are controversial and not widely accepted.
Azithromycin blocks transpeptidation by binding to 50s ribosomal subunit of susceptible organisms and disrupting RNA-dependent protein synthesis at the chain elongation step.
• Absorption Reduced by food (capsule formulation); peak plasma concentrations after 2-3 hours.
• Distribution Extensive into the tissues (concentrations higher than those in blood), WBC (high concentrations), CSF (small amounts). Metabolism Liver (demethylation).
• Excretion Via the bile (as unchanged drug and metabolites); via the urine (6% of the dose). Elimination half-life About 68 hours.