Corpus luteum and placenta secretes progestational which is a major steroid. Main function of progesterone is to function on uterus, the mammary glands, and the brain. The other functions of progesterone are to maintain the pregnancy, mammary tissue development so to produce milk. PROGESTERONE IS A FEMALE HORMONE ESSENTIAL FOR THE REGULATION OF OVULATION AND MENSTRUATION.
a.) Pharmacodynamics: A naturally occurring hormone which is a female sex hormone. To understand the pharmacodynamics of progesterone is important to know about the process of a woman’s normal menstrual cycle, when the egg matures it is released from the ovaries (ovulation) which then maintain the level of progesterone to avoid further release of eggs. Progesterone levels are maintained high in case pregnancy occurs to maintain endometrium (inner wall of uterus). Progesterone levels falls in the body if there is no pregnancy, resulting in a menstrual period.
• Absorption: – A prolonged half-life of upto 25-50 hours is absorbed.
• Protein Binding: – Unto 99% of protein binding is absorbed.
• Metabolism: – Progesterone undergoes first pass metabolism when administered orally but on IM it avoids extensive first pass hepatic metabolism.
• Route of Elimination: – Through urine and bile. Its metabolites are excreted mainly by the kidneys.
• For infertility among women.
• For treatment of amenorrhea.
• For reduction of the incidence of endometrial hyperplasia
• As well as for the treatment of abnormal uterine bleeding