(PANTOPRAZOLE 40 MG & DOMPERIDONE 30 MG)
M.R.P: – 890
Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease whereas Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.
Pharmacokinetics: – 1. Pantoprazole:
Bioavailability: – The absolute bioavailability from the tablet was found to be about 77 %.
2. Domperidone: Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of Domperidone are related to its peripheral dopamine receptor blocking properties.
Indications: Antacids Antireflux Agents & Antiulcerants / GIT Regulators, Antiflatulents Anti-Inflammatories