ZIMFE P
November 30, 2017
SIGMERO-T
November 30, 2017

ZUTER A SYP

(TERBUTALINE 1.25 MG, BROMHEXINE 15 MG, GUAIPHENSIN 50 MG & MENTHOL 2.5 MG)

SKU: 3e828d69c419 Category:
Description

PACKING: – 100 ML
M.R.P: -65/-
Terbutaline Sulphate is a selective beta2 -adrenergic agonist which predominantly stimulates
beta2-receptors, thus producing relaxation of bronchial smooth muscle.
Guaiphenesin, by increasing respiratory tract fluid, reduces the viscosity of tenacious secretions and
acts as an expectorant.
Bromhexine HCl is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. It is secretolytic, increasing the production of serous mucus in the respiratory tract and makes the phlegm thinner and less viscous
Menthol is also classified as an expectorant.
PHARMACODYNAMICS: –
Terbutaline Sulphate: Terbutaline is a selective beta2 – adrenergic causing bronchodilation; increase in mucociliary clearance; suppression of oedema and anti-allergic effects.
Guaiphenesin: Guaiphenesin is thought to exert its pharmacological action by stimulating receptors in the gastric mucosa. This increases the output from secretory glands of the gastrointestinal system and reflexly increases the flow of fluids from glands lining the respiratory tract. The result is an increase in volume and decrease in viscosity of bronchial secretions.
Bromohexien HCl: Bromhexine is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. It is secretolytic, increasing the production of serous mucus in the respiratory tract and makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect by helping the cilia transport the phlegm out of the lungs. For this reason it is often added to cough syrups
PHARMACOKINETICS: –
Terbutaline Sulphate:
• Absorption: – Approximately 30-50% if administered orally and well absorbed subcutaneously.
• Route of Elimination: About 90% of the drug was excreted in the urine at 96 hours after subcutaneous administration, with about 60% of this being unchanged drug. It appears that the sulfate conjugate is a major metabolite of terbutaline and urinary excretion is the primary route of elimination.

• Half Life: 5.5-5.9 hours.
Guaiphenesin: –
• Absorption: Rapidly absorbed from the GI tract.
• Metabolism: Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine.
• Half Life: 1 hour.
Bromohexine Hydrochloride:
• Absorption: Bromohexine hydrochloride is rapidly absorbed from the gastrointestinal tract.
• Distribution: It is widely distributed to body tissues and is highly bound to plasma proteins.
• Metabolism: It undergoes extensive first-pass metabolism in the liver.
• Route of Elimination: About 85 to 90% of a dose is excreted in the urine mainly as metabolites.
• Half Life: It has a terminal elimination half-life of up to about 12 hours.
INDICATIONS: –
Terbutaline sulphate: -The bronchial muscles relax and Guaiphenesin along with Menthol acts as a expectorant reducing the viscosity and helps to loosens mucus in your lungs. Whereas,
Bromohexine HCl contributes to a secretomotoric effect by helping the cilia transport the phlegm out of the lungs. Thereby relieving the patient of acute or chronic cough and other bronchospastic disorders.

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