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Cefoperazone & Sulbactam Injection-Manufacturers, Supplier, Third Party Contract Manufacturing & PCD Pharma Franchise

Cefoperazone & Sulbactam Injection


SKU: b937eff2b175 Categories: , Send Enquiry

Packing: – Vial
M.R.P: – 159
a.) Pharmacodynamics: – Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits Transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporin’s like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis b.)Pharmacokinetics: –
• Absorption: Orally not well absorbed & should be given parenterall.
• Distribution: widely distributed & good CSF penetration.
• Metabolism: It is not significantly metabolized inside the body.
• Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.
a.) Pharmacodynamics: – Sulbactam has no significant antimicrobial activity, despite sharing the BETA-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Sulbactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against?-lactamase-secreting resistant bacteria. It is usually given in combination with Amoxycillin. a.)It is used to increase the antibacterial spectrum of penicillin and cephalosporin against penicillinase-producing and beta-lactamase-producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to Ampicillin alone.
1. Cefoperazone: Meningitis Biliary infections Septicemia Infections in immune compromised patients Urinary tract &genital tract infections Surgical prophylaxis Skin & soft tissue infections Bone & Joint infections Gonorrhea, Peritonitis.
2. Sulbactam Skin infections Intra abdominal infections Gynecologic infections

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Cefoperazone 500 mg & Sulbactam 500 mg

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