XYLID-P TAB
November 30, 2017
OXECRA SUSP.
November 30, 2017

ZIMFE-P TAB.

(ACECLOFENAC 100 MG & PCM 500 MG).

Description

Packing: – 10X10
M.R.P: – 490
Aceclofenac 100mg &pcm 325mg the combination medication is used to treat pain and inflammation. It is and excellent pain reliever and anti-inflammatory analgesic medicine. Its is used in the treatment of chronic pains. Aceclofenac has positive effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity which is overcome with the combination of aceclofenac, thereby enhancing the overall efficacy of the product as a whole. PHARMACOLOGY
PHARMACOKINETICS:
• Absorption: – Aceclofenac: Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hours after oral admin.
• Distribution: – Aceclofenac: >99.7% bound to plasma proteins; distributes into synovial fluid.
Paracetamol: Distributes throughout most fluids of the body.
• Metabolism: – Aceclofenac: Probably metabolized by CYP2C9; average plasma elimination
• Half-Life: 4-4.3 hours. Paracetamol: Mainly metabolized hepatically; plasma elimination half-life: 1-4 hours.
• Excretion: – Aceclofenac: About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites.
Paracetamol: Most metabolites are removed in the urine within 24 hours.
INDICATIONS:-
• Anti-inflammatory,
• Antipyretic agents used to treat pain and swelling.

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