DOCRU- TAB
November 30, 2017
MO-ZINE TAB
November 30, 2017

LINEWAR 600 TAB

(LINEZOLID 600 MG)

SKU: 0120739565cb Categories: ,
Description

Packing: – 10X1X4
M.R.P: – 2400
COMPOSITION: LINEZOLID 600MG
PHARMACOLOGY
PHARMACOKINETICS:
• Absorption: Owing to hepatic first-pass metabolism, its bioavailability is only about 60%.
• Distribution: Plasma protein binding of ondansetron as measured in vitro was 70% to 76%, over the pharmacologic concentration range of 10 to 500 ng/mL. Circulating drug also distributes into erythrocytes.
• Metabolism: Ondansetron is extensively metabolized in humans, with approximately 5% of a radiolabeled dose recovered as the parent compound from the urine. The primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation.
• Elimination: In adult cancer patients, the mean ondansetron elimination half-life was 4.0 hours, and there was no difference in the multidose pharmacokinetics over a 4-day period.
INDICATIONS:
• Prevention of nausea and vomiting associated with highly emetogenic chemotherapy, including cisplatin 50mg/m2.
• Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic chemotherapy.
• Prevention of nausea and vomiting associated with radiotherapy in patients receiving total body irradiation, single high-dose fraction to the abdomen, or daily fractions to the abdomen.
• Prevention of post-op nausea and vomiting.

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