COMPOSITION: – CEFPODOXIME 200 MG + OFLOXACIN 200 MG
PACKING: – 10X1X10
Cefpodoxime Proxetil is a third-generation cephalosporin antibiotic, this is a prodrug absorbed from the GIT and to obtain cefpodoxime ,which is its active metabolite, de-esterification takes place.
Ofloxacin is a fluoroquinolone class of antibiotics and treats a wide range of bacterias. It inhibits the growth of bacteria by hindering its reproduction and repair of its genetic material i.e. DNA.
MECHANISM OF ACTION: – The bacterial cell wall synthesis is interrupted. The cell wall synthesis is inhibited via the active metabolite of Cefpodoxime which has high affinity towards penicillin binding protein, this bonding interrupts the production of peptidoglycan which is the main constituent of bacterial cell walls. Thus the cell wall formation gets hindered and bacterial growth ceases.
MECHANISM OF ACTION: – Being a broad-spectrum antibiotic it is active against both Gram-positive and Gram-negative bacteria. It inhibits the function of DNA gyrase, which is responsible for prohibiting the replication of DNA, thereby inhibiting bacterial cell division.
As the combination reacts to a broad spectrum of antibiotics so it can be indicated