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Aceclofenac & Thiocolchicoside Tablets-Manufacturers, Supplier, Third Party Contract Manufacturing & PCD Pharma Franchise

Aceclofenac & Thiocolchicoside Tablets


Packing: – 10X10
M.R.P: – 1520
Mechanism of Action: – Thiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.
Mechanism of Action: – It inhibits cyclo-oxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils. Aceclofenac is also an NSAID with greater COX-2 specificity.
• Absorption- It is rapidly and completely absorbed after oral administration
• Distribution- Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma.
• Metabolism- Metabolized into metabolites in the liver. Main metabolite is 4-hydroxyaceclofenac Excretion- It is excreted through urine mainly as conjugated hydroxymetabolites
THIOCOLCHICOSIDE Degenerative vertebral disorders Torticollis Dorsal pain Low back pain Traumatological disorders Neurological disorders
ACECLOFENAC Ankylosing spondylitis Osteoarthritis Symptomatic treatment of pain and inflammation in Post-Traumatic pain Cervical pain Low back pain Acute gout.

Brand Name



Aceclofenac 100 mg & Thiocolchicoside 4 mg

Pack Type


Pack Size

10 X10

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