Ceftriaxone & Tazobactum Injection is the composition of the medication belonging to the brand ULFAZ-T Injection which is used for treating bacterial infections. Ceftriaxone interferes with the biosynthesis of the peptidoglycan component of the bacterial cell way by binding to and inactivating penicillin-binding proteins (PBPs). Tazobactam is a penicillanic acid sulfone derivative with lactamase inhibitory properties. It enhances the activity of lactam antibacterials against lactamase-producing bacteria.
Distribution: – Ceftriaxone: 98% bound to plasma proteins; crosses the blood-brain barrier.
Tazobactam: About 30% bound to plasma proteins; widely distributed to tissues and body fluids. Excretion: –
Elimination half-life is about 8.7 hours; 33-67% removed as unchanged drug. Tazobactam: Removed mainly via kidneys with 80% of an administered dose as an unchanged drug
Pharmacodynamics: – Ceftriaxone is a 3rd generation cephalosporin that exerts its bactericidal action against both gram-positive & gram-negative organisms by inhibiting bacterial cell wall synthesis. Ceftriaxone inhibits transpeptidase & thus prevents cross-linking of the bacterial cell walls. Transpeptidase & associated proteins constitute various types of specific binding proteins that have an affinity for cephalosporins like Ceftriaxone.
• Lower respiratory tract infections and community-acquired pneumonia.
• Acute bacterial otitis media.
• Skin and skin structure infections.
• Urinary tract infections. Uncomplicated gonorrhea.
• Pelvic inflammatory disease.
• Bacterial septicemia.
• Intra-abdominal infections.
• Bacterial Meningitis.
The doctor, nurse, or healthcare professional injects the composition of the injection in the vein or the muscle based on the health condition of the person. It is advised not to administer the dose of the injection on the choice.
The instilling of the injection may or may not make the person uncomfortable from the following side effects :
There are certain precautions that are to be taken care of during or before the instilling of the injection :
Before undergoing the urine test, the person is advised to tell the doctor that he is undergoing the treatment of this injection.
Being an antibiotic the composition of the medication helps in treating the bacterial infections only. The composition of the medication does not treat viral infections.