Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably, the drug has a 100 times higher affinity for bacterial DNA gyrase than for mammals. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Mechanism of action:- Ofloxacin acts on DNA gyrase and topoisomerase IV, enzymes which, like human topoisomerase, prevent the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
• ABSORPTION: -Bioavailability of ofloxacin in the tablet formulation is approximately 98%
• METABOLISM: – Hepatic
• ROUTE of ELIMINATION: – Elimination is mainly by renal excretion. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Four to eight percent of an ofloxacin dose is excreted in the feces. This indicates a small degree of biliary excretion of ofloxacin.
• HALF-LIFE:- 9 HOURS
Indications: – For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhea.
Some of the most significant uses of ofloxacin oral suspension are listed below. Mostly this suspension is used to treat bacterial infections of different body organs.
Keep in mind the following protocol before taking this medication.
Some of the observable side effects of Ofloxacin syrup in the small minority of the population are as follows:
It is advised to discuss the following health conditions with your doctor before taking this medication. The following health conditions can interfere with the proper functioning of this medication in the body.
Can a person consume alcohol with this medication?
No, it is not recommended to drink alcohol with this medication.
When do I stop taking this Ofloxacin Syrup?
It is advised to complete the full course of this medication.
Does ofloxacin syrup cause sleep issues?
Yes, ofloxacin is known to cause insomnia. Consult a doctor if you’re having trouble sleeping.
Is this medication safe for children?
Yes, if prescribed by the doctor.
What if a person missed a dose?
Try to take medication on time but if a person missed a dose, then the next doses should be taken on time.
Ofloxacin 50 mg