Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably, the drug has a 100 times higher affinity for bacterial DNA gyrase than for mammals. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Mechanism of action:-Ofloxacin acts on DNA gyrase and topoisomerase IV, enzymes which, like human topoisomerase, prevent the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division. ABSORPTION: -Bioavailability of ofloxacin in the tablet formulation is approximately 98%
METABOLISM: – Hepatic
ROUTE of ELIMINATION: – Elimination is mainly by renal excretion. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Four to eight percent of an ofloxacin dose is excreted in the feces. This indicates a small degree of biliary excretion of ofloxacin.
HALF-LIFE:- 9 hours
Mechanism of Action: – Ornidazole is a nitroimidazole that has broad-spectrum antibiotic activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves
1. Drug enters the cell by diffusion,
2. Nitro group of the drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which exerts cytotoxic action by damaging DNA and other critical biomolecules.
3. DNA helix destabilization &strand breakage has been observed.
• Absorption: Well absorbed orally,
• Distribution: Widely distributed,
• Metabolism: Metabolized in the liver by conjugation,
• Excretion: Excreted in urine and a small portion is excreted in bile
• Half-Life: – 12 to 14 hours
• GIT infections
• Acute diarrhea of mixed origin
• Dental infections
• Gynecological infections
• ENT infections
• Skin & soft tissue infections
• Surgical infections
Ofloxacin and Ornidazole oral suspension are effective in the treatment of the following diseases:
Some of the associated side effects of this suspension are listed below. These side effects were observed in a minority of the population who took this suspension.
Keep in mind the following protocol before taking this medication.
It is advised to discuss the following health conditions with your doctor before taking this medication. The following health conditions can interfere with the proper functioning of this medication in the body.
Is this medication safe for children?
Yes, this medication is safe for children if prescribed by a doctor.
Is this medication safe for pregnant women?
Yes, if advised by the healthcare professional.
Is this medication habit-forming?
No, this medication does not form a habit.
Can a person skip my medication?
No, one should never skip the [prescribed medication before the Doctor’s instruction.
Can this medication cause allergies?
Yes, some components of this medication can cause allergies.
Ofloxacin 50 mg & Ornidazole 50 mg