PANTOPRAZOLE & DOMPERIDONE CAPSULES

Packing: -10X10
M.R.P: – 890

Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease whereas Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.
Pharmacology
Pharmacokinetics: – 1. Pantoprazole:

• • Absorption: – Pantoprazole is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production. Pantoprazole is unstable in acid and is administered orally in the form of an enteric-coated tablet Pantoprazole is completely and rapidly absorbed after oral administration.

Bioavailability: – The absolute bioavailability from the tablet was found to be about 77 %.

• Metabolism: – Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system. Elimination: – Renal elimination represents the major route of excretion (about 80%) for the metabolites of Pantoprazole; the rest is excreted with the feces.

2. Domperidone: Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of Domperidone are related to its peripheral dopamine receptor blocking properties.

• Absorption: – Domperidone is rapidly absorbed after oral administration.
• Protein Binding: – Domperidone is 91-93% bound to plasma proteins.
• Metabolism: –Domperidone undergoes rapid and extensive hepatic metabolism
• Elimination: – Urinary and faecal excretions amount to 31 and 66% of the oral dose respectively.

Indications: Antacids Antireflux Agents & Antiulcerants / GIT Regulators, Antiflatulents Anti-Inflammatories

Uses of Pantoprazole & Domperidone Capsule

The composition of Pantoprazole & Domperidone Capsule is helpful for gastroesophageal reflux disease (GERD), heartburn due to hyperacidity, inflammation of the food pipe, and peptic ulcer. The person suffering from the problem of indigestion can take the help of this medication. The medication helps in providing relief from stomach pain. The excessive amount of stomach acid is prevented with the help of this medication. The person also gets relief from the vomiting, nausea, etc. the stomach acid is reduced with the help of this medication. The person gets relief from the stomach-related issues and is able to improve his indigestion. 

Directions for Use

The best time considered to take the tablet is at least an hour before the meal. It is considered best to swallow the whole tablet with a glass of water. The intake of the tablet should not be administered own as the intake of the tablet is based on the medical condition of the person. 

Side Effects Of Pantoprazole & Domperidone Capsule

There are some common side effects that can occur after the intake of the tablet. Although these side effects disappear on their own and do not cause any negative effects. The common side effects which occur after the intake of the medication are as follows :

• Headache
• Nausea
• Abdominal pain
• Vomiting
• Dizziness

Precautions To Be Taken

During the treatment, some people require precautions to consider. The precautions are as follows :

• Before the use of the medication, the person is advised to tell the doctor about his medical history including gastric cancer, liver problem, etc. 
• The woman who is planning to become pregnant is advised to consult the doctor before the use of the medication
• The person having low vitamin B12 (anemia) is advised to consult the doctor before the intake of the medication. 

Frequently Asked Questions (FAQs)

1. Can the person drive the vehicle after taking Pantoprazole & Domperidone Capsule?

It is not considered safe for the person to drive the vehicle during the treatment. If the person is physically stable and mentally focussed, then only he is advised to drive the vehicle or to do the work that needs concentration. 

2. Is the consumption of alcohol considered safe during the treatment?

No, it is not considered safe to consume alcohol while undergoing the treatment.