MEDICATION USED FOR
Polymyxin B (Polyfix) used to treat bacterial infections . Polymyxin B (Polyfix) to reduce development of drug resistant bacteria and maintain the effectiveness of Polymyxin B(Polfix) should be used only to treat or prevent infection that are proven or strongly suspected to be caused by bacteria . Polymyxin B.(Polyfix) an effective antibiotic medicines to treat infection of urinary tract ,eye.ear. skin, bloodstream and layers covering the brain (menings) caused by sensitive gram-negative bacteria. Polymyxin B (Polfix) are used to treatment of gram-negative bacterial infections. Polymyxin B (Polyfix) is an antibiotics primarily used for resistant gram-negative infections. Polymyxin B(Polyfix) derived from the bacterium Bacillus polymyxa. Polymyxin B(Polyfix) composed a number of related compound Polymyxin B(Polyfix) has a bacterioidal action against almost all gram- negative bacilli Polymyxin B (Polyfix) binds to the cell membrane and alter its structure , making its more permeable . Polymyxin B (Polymyxin) are used in the tropical first -aid prepration Neosporin.
MECHANISM OF ACTION
Polymyxin B ( Polyfix) are cationic detergent and thoughts to interact with the phospholipids of bacterial cell membrane, thereby leading to increased cell wall permeablility and cell death . Polymyxin B (Polyfix) works by killing bacterial Polymyxin B(Polyfix) interact with lepopolysaccharides (LPS) of the outer membranes of gran=-negative bacteria and are subsequently taken up via the self -promoted uptake pathway . After binding to Lopiproteinsaccharide (LPS) is the outer membraneof gram-negative bacteria, Polymyxin B (Polyfix) distrupt both the outer and inner membranes . The hydrophobic tail is important in causing membrane damage . Suggesting a detergent like mode of actions.