SIGMERO-1000

COMPOSITION: – MEROPENEM 1000 MG

PACKING: – VIAL

M.R.P:- 1195

It is a carbapenem antibiotic active against broad spectrum of bacteria both gram positive and negative. Unlike other antibiotics, Meropenem acts by penetrating the cell wall of the bacteria and interrupting the growth of major cell wall components leading to cell death.

PHARMACOLOGY

PHARMACODYNAMICS: – The main action of meropenem is to inhibit bactericidal activity by preventing the formation of cell wall. Meropenem acts against both gram negative and gram positive bacteria’s, the drug is potential to penetrate the cell wall bacterias to reach penicillin-binding- protein (PBP) targets.

PHARMACOKINETICS: –

• ROUTE OF ELIMINATION: – Meropenem when administered orally is absorbed about 70% which is then recovered in the urine in an unchanged form.
• HALF-LIFE: – Approximately 1 hour but it differs in various age groups.

INDICATIONS: –

As stated above the drug has a broad spectrum against gram positive and gram negative bacterias, so is its uses. It is indicated for: –

• The treatment of bacterial meningitis
• Skin infections