The salt composition of the NIZBRO 200 is Acebrophylline tablets and that helps to treat the symptoms of Asthma and a lung disorder in which the flow of air to the lungs is blocked. Acebrophylline has 3 actions namely bronchodilation, mucoregulation & anti-inflammatory action that helps in providing relaxation to the lungs and also relax the muscles of the air passages, and help to make breathing easy.
Precautions for Acebrophylline Tablets
Acebrophylline tablets are taken as your doctor suggests to you. This medicine is taken with the food in the evening. But the patient must take this dose at the same time every day to get more benefits from it. Your doctor will decide how many doses you need to take for the improvement. The patients should take this medicine for as long as their doctors recommend them. You should not miss a single dose of this medicine, if you forget to take then take it as soon as you think about it. For better results, you should take this medicine regularly.
Side Effects of Acebrophylline Tablets
The most common side effects of Acebrophylline tablets are nausea, headache, vomiting, and abdominal upset or discomfort. If any side effects seriously bother you then you just contact your doctor quickly. It is advised to do not to take alcohol or smoke during the medication.
PHARMACODYNAMICS: Acebrophylline inhibits intracellular phosphodiesterase associated significantly reduce the airway inflammation and obstruction in chronic stages. Acebrophylline increases the synthesis and release of alveolar surfactant, resulting in triple action: mucoregulation, stimulation of bronchoalveolar clearance, and anti-inflammatory-antireactive effect.
In patients with chronic obstructive bronchitis, given the drug for 10-20 days, there was a good reduction in expectorate Viscosity.with cAMP levels and facilitates bronchial muscles relaxation. Acebrophylline selectively inhibits phosphatidylcholine and phospholipase A, TNF-alpha and leukotrienes. Inhibition of such pro-inflammatory mediators can.
• Absorption: – 200mg oral acebrophylline, the two components of the molecule ambroxol and theophylline-7-acetic acid are released in the stomach and absorbed in the intestine, reaching optimal concentrations of ambroxol within 2hrs and of theophylline-7-acetic acid after 1 hr.
• Half-Life: – The plasma half life varies from 4 to 9 hrs after oral administration.
• Metabolism: – The drug is metabolized in the liver and eliminated renally.
Indications :- Treatment of adult patients with COPD and bronchial asthma.
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